DDT IN THE ENVIRONMENT: SOURCES, POLLUTION PREVENTION STRATEGIES AND HUMAN HEALTH IMPLICATIONS: A COMPREHENSIVE REVIEW
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This review addresses the environmental impact of dichlorodiphenyltrichloroethane (DDT), with an emphasis on its origin, monitoring techniques, pollution tactics, and human health consequences. DDT, a persistent organic pollutant, has been extensively used in agriculture and public health, resulting in its broad dispersion in numerous environments. This study examined the basic causes of DDT pollution, including historical use, agricultural runoff, and incorrect disposal procedures. Furthermore, this study investigated solutions for reducing DDT contamination, including regulatory measures, alternative pest control tactics, and safe disposal procedures. The effects of DDT exposure on human health, including its association with cancer, reproductive abnormalities, and neurological damage, have also been investigated. Overall, this study emphasizes the significance of continued efforts to monitor and reduce DDT pollution in order to protect human health and the environment.
Ware, G. W. (1974). Ecological history of DDT in Arizona. Journal of the Arizona Academy of Science, 9(2), 61-65.
Popivanov, I., Petkova, T., Doycheva, V., Doychinova, T., Angelov, I., & Shalamanov, D. (2015). Vector control—development and improvement of the modern chemical insecticides. Journal of Pharmacy and Pharmacology, 3, 1-8.
Sharma, A., Kumar, V., Shahzad, B., Tanveer, M., Sidhu, G. P. S., Handa, N., ... & Thukral, A. K. (2019). Worldwide pesticide usage and its impacts on ecosystem. SN Applied Sciences, 1, 1-16.
Attaran A., Liroff R., Maharaj R. Doctoring malaria, badly: the global campaign to ban DDT.DDT for malaria control should not be banned Commentary: Reduction and elimination of DDT should proceed slowly //Bmj. – 2000. – Т. 321. – №. 7273. – С. 1403-1405.
Virkutyte, J., & Varma, R. (2010). Treatment of micropollutants in water and wastewater. IWA Publishing.
Jensen, S., Johnels, A. G., Olsson, M., & Otterlind, G. (1969). DDT and PCB in marine animals from Swedish waters. Nature, 224(5216), 247-250.
Walker, K. C., Goette, M. B., & Batchelor, G. S. (1954). Pesticide residues in foods, dichlorodiphenyltrichloroethane and dichlorodiphenyldichloroethylene content in prepared foods. Journal of Agricultural and Food Chemistry, 2(20), 1034-1037.
Cameron, G. R., & Burgess, F. (1945). The toxicity of DDT. British Medical Journal,
(4407), 865.
Hayes, W. J., Durham, W. F., & Cueto, C. (1956). The effect of known repeated oral doses of chlorophenothane (DDT) in man. Journal of the American Medical Association, 162(9), 890-897.
Laws Jr, E. R., Curley, A., & Biros, F. J. (1967). Men with intensive occupational exposure to DDT: A clinical and chemical study. Archives of Environmental Health: An International Journal, 15(6), 766-775.
Unger, M., & Olsen, J. (1980). Organochlorine compounds in the adipose tissue of deceased people with and without cancer. Environmental Research, 23(2), 257-263.
Hazlett, M. P. T. (2003). The story of “Silent Spring” and the ecological turn. University of Kansas.
Edwards, J. G. (2004). DDT: A case study in scientific fraud. Journal of American Physicians and Surgeons, 9, 83-88.
Van Den Berg, H., Zaim, M., Yadav, R. S., Soares, A., Ameneshewa, B., Mnzava, A., ... & Ejov, M. (2012). Global trends in the use of insecticides to control vector-borne diseases. Environmental health perspectives, 120(4), 577-582.
Zeinab, H. M., Refaat, G. A. E. E., & El-Dressi, A. Y. (2011). Organochlorine pesticide residues in human breast milk in El-Gabal Al-Akhdar, Libya. In International Conference on Life Science and Technology IPCBEE Singapore: IACSIT Press.
Dogheim, S. M., Mohamed, E. Z., Gad Alla, S. A., El-Saied, S., Salama, E. Y., Mohsen, A. M., & Fahmy, S. M. (1996). Monitoring of Pesticide Residues in Human Milk, Soil, Water, and Food Samples Collectedfrom Kafr El-Zayat Governorate. Journal of AOAC International, 79(1), 111-116.
Hernández, L. M., Fernández, M. A., Hoyas, E., González, M. J., & García, J. F. (1993). Organochlorine insecticide and polychlorinated biphenyl residues in human breast milk in Madrid (Spain).
Thuy, T. T. (2015). Effects of DDT on environment and human health. Journal of Education and Social Sciences, 2(1), 108-14.
Eskenazi, B., Chevrier, J., Rosas, L. G., Anderson, H. A., Bornman, M. S., Bouwman, H., ... & Stapleton, D. (2009). The Pine River statement: human health consequences of DDT use. Environmental health perspectives, 117(9), 1359-1367.
Biscoe, M. L., Mutero, C. M., & Kramer, R. A. (2004). Current policy and status of DDT use for malaria control in Ethiopia, Uganda, Kenya and South Africa (Vol. 95). IWMI.
World Health Organization. (2011). The use of DDT in malaria vector control: WHO position statement (No. WHO/HTM/GMP/2011). World Health Organization.
Cohn, B. A., Wolff, M. S., Cirillo, P. M., & Sholtz, R. I. (2007). DDT and breast cancer in young women: new data on the significance of age at exposure. Environmental health perspectives, 115(10), 1406-1414.
Burns, A. S. Y. W., Jaros, E., Cole, M., Perry, R., Pearson, A. J., & Lunec, J. (2002). The molecular pathology of p53 in primitive neuroectodermal tumours of the central nervous system. British journal of cancer, 86(7), 1117-1123.
La Merrill, M. A., Vandenberg, L. N., Smith, M. T., Goodson, W., Browne, P., Patisaul, H. B., ... & Zoeller, R. T. (2020). Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification. Nature Reviews Endocrinology, 16(1), 45-57.
Wolff, M. S., Toniolo, P. G., Lee, E. W., Rivera, M., & Dubin, N. (1993). Blood levels of organochlorine residues and risk of breast cancer. JNCI: Journal of the National Cancer Institute, 85(8), 648-652.
Barsouk, A., Thandra, K. C., Saginala, K., Rawla, P., & Barsouk, A. (2021). Chemical risk factors of primary liver cancer: an update. Hepatic Medicine: Evidence and Research, 179-188.
Cocco, P., Kazerouni, N., & Zahm, S. H. (2000). Cancer mortality and environmental exposure to DDE in the United States. Environmental health perspectives, 108(1), 1-4.
Katano, H. (2018). Pathological features of Kaposi’s sarcoma-associated herpesvirus infection. Human herpesviruses, 357-376.
Tokudome, S., Maeda, Y., Fukada, K., Teshima, D., Asakura, T., Sueoka, E., ... & Tokunaga, O. (1991). Follow-up of asymptomatic HTLV-I carriers among blood donors in Kyushu, Japan. Cancer Causes & Control, 2, 75-78.
Cocco, P., Fadda, D., Billai, B., D'Atri, M., Melis, M., & Blair, A. (2005). Cancer mortality among men occupationally exposed to dichlorodiphenyltrichloroethane. Cancer research, 65(20), 9588-9594.
De Coster, S., & Van Larebeke, N. (2012). Endocrine-disrupting chemicals: associated disorders and mechanisms of action. Journal of environmental and public health, 2012.
Bornman, R., & Aneck-Hahn, N. (2014). Endocrine Disruptors and Male Infertility. In Male Infertility: A Complete Guide to Lifestyle and Environmental Factors (pp. 193-210). New York, NY: Springer New York.
Prins, G. S., & Korach, K. S. (2008). The role of estrogens and estrogen receptors in normal prostate growth and disease. Steroids, 73(3), 233-244.
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., ... & Zoeller, R. T. (2015). EDC-2: the Endocrine Society's second scientific statement on endocrine-disrupting chemicals. Endocrine reviews, 36(6), E1-E150.
Kelce, W. R., Stone, C. R., Laws, S. C., Gray, L. E., Kemppainen, J. A., & Wilson, E. M. (1995). Persistent DDT metabolite p, p'–DDE is a potent androgen receptor antagonist. Nature, 375(6532), 581-585.
Hinton, R. H., Mitchell, F. E., Mann, A., Chescoe, D., Price, S. C., Nunn, A., ... & Bridges, J. W. (1986). Effects of phthalic acid esters on the liver and thyroid. Environmental health perspectives, 70, 195-210.
Howdeshell, K. L., Hotchkiss, A. K., Thayer, K. A., Vandenbergh, J. G., & Vom Saal, F. S. (1999). Exposure to bisphenol A advances puberty. Nature, 401(6755), 763-764.
Slotkin, T. A. (2004). Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates. Toxicology and applied pharmacology, 198(2), 132-151.
Eskenazi, B., Marks, A. R., Bradman, A., Fenster, L., Johnson, C., Barr, D. B., & Jewell, N. P. (2006). In utero exposure to dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) and neurodevelopment among young Mexican American children. Pediatrics, 118(1), 233-241.
Shelton, J. F., Geraghty, E. M., Tancredi, D. J., Delwiche, L. D., Schmidt, R. J., Ritz, B., ... & Hertz-Picciotto, I. (2014). Neurodevelopmental disorders and prenatal residential proximity to agricultural pesticides: the CHARGE study. Environmental health perspectives, 122(10), 1103-1109.
Bouchard, M. F., Bellinger, D. C., Wright, R. O., & Weisskopf, M. G. (2010). Attention-deficit/hyperactivity disorder and urinary metabolites of organophosphate pesticides. Pediatrics, 125(6), e1270-e1277.
Ribas-Fitó, N., Torrent, M., Carrizo, D., Muñoz-Ortiz, L., Júlvez, J., Grimalt, J. O., & Sunyer, J. (2006). In utero exposure to background concentrations of DDT and cognitive functioning among preschoolers. American journal of epidemiology, 164(10), 955-962.
Slotkin, T. A., Card, J., & Seidler, F. J. (2014). Prenatal dexamethasone, as used in preterm labor, worsens the impact of postnatal chlorpyrifos exposure on serotonergic pathways. Brain research bulletin, 100, 44-54.
Richardson, J. R., Roy, A., Shalat, S. L., Von Stein, R. T., Hossain, M. M., Buckley, B., ... & German, D. C. (2014). Elevated serum pesticide levels and risk for Alzheimer disease. JAMA neurology, 71(3), 284-290.
Beard, J., Marshall, S., Jong, K., Newton, R., Triplett-McBride, T., Humphries, B., & Bronks, R. (2000). 1, 1, 1-trichloro-2, 2-bis (p-chlorophenyl)-ethane (DDT) and reduced bone mineral density. Archives of Environmental Health: An International Journal, 55(3), 177-180.
Lee, D. H., Lind, P. M., Jacobs Jr, D. R., Salihovic, S., van Bavel, B., & Lind, L. (2012). Background exposure to persistent organic pollutants predicts stroke in the elderly. Environment international, 47, 115-120.
ATSDR, T. (2002). Profile for DDT, DDE and DDD, US Department of Health and Human Services. Public Health Service, 497, 17-26.
Mamane, A., Raherison, C., Tessier, J. F., Baldi, I., & Bouvier, G. (2015). Environmental exposure to pesticides and respiratory health. European respiratory review, 24(137), 462-473.
Lesueur, C., Gartner, M., Mentler, A., & Fuerhacker, M. (2008). Comparison of four extraction methods for the analysis of 24 pesticides in soil samples with gas chromatography–mass spectrometry and liquid chromatography–ion trap–mass spectrometry. Talanta, 75(1), 284-293.
Shinde, R., Pardeshi, A., Dhanshetty, M., Anastassiades, M., & Banerjee, K. (2021). Development and validation of an analytical method for the multiresidue analysis of pesticides in sesame seeds using liquid-and gas chromatography with tandem mass spectrometry. Journal of Chromatography A, 1652, 462346.
Zhao, Q., Lu, D., Zhang, G., Zhang, D., & Shi, X. (2021). Recent improvements in enzyme-linked immunosorbent assays based on nanomaterials. Talanta, 223, 121722.
Dodson, R., Perovich, L., Nishioka, M., Spengler, J., Vallarino, J., & Rudel, R. (2011). Long-term Integrated Sampling of Semivolatile Organic Compounds in Indoor Air: Measurement of Emerging Compounds Using Novel Active and Passive Sampling Methods. Epidemiology, 22(1), S160.
UNEP. (2009). Stockholm Convention on Persistent Organic Pollutants: Ammendments to Annexes A, B, & C.
Moss, S. (2019). Integrated weed management (IWM): why are farmers reluctant to adopt non‐chemical alternatives to herbicides? Pest management science, 75(5), 1205-1211.
Mansouri, A., Cregut, M., Abbes, C., Durand, M. J., Landoulsi, A., & Thouand, G. (2017). The environmental issues of DDT pollution and bioremediation: a multidisciplinary review. Applied biochemistry and biotechnology, 181, 309-339.
Dunlap, T. (2014). DDT: scientists, citizens, and public policy (Vol. 1080). Princeton University Press.
Rogan, W. J., & Chen, A. (2005). Health risks and benefits of bis (4-chlorophenyl)-1, 1, 1-trichloroethane (DDT). The Lancet, 366(9487), 763-773.